2. Cytogenetic and Genetic Abnormalities in Leukemia
نویسندگان
چکیده
منابع مشابه
Cytogenetic and molecular abnormalities in chronic myelomonocytic leukemia.
Chronic myelomonocytic leukemia (CMML) is a clonal stem cell disorder associated with peripheral blood monocytosis and an inherent tendency to transform to acute myeloid leukemia. CMML has overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms. Clonal cytogenetic changes are seen in ~30%, whereas gene mutations are seen in >90% of patients. Common cytogenetic abnorma...
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ACUTE LYMPHOBLASTIC leukemias (ALL) are characterized by clonal proliferation, accumulation, and tissue infiltration of neoplastic cells. They are mainly regarded as childhood diseases, with an early incidence peak at 2 to 5 years of age, where they represent about 80% of the childhood leukemias in the United States, and occur with an incidence of up to 30 cases per 1 million population per yea...
متن کاملDifferential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML
Acute myeloid leukemia (AML) is a haematological malignancy characterized by the excessive proliferation of immature myeloid cells coupled with impaired differentiation. Many AML cases have been reported without any known cytogenetic abnormalities and carry no mutation in known AML-associated driver genes. In this study, 200 AML cases were selected from a publicly available cohort and different...
متن کاملCytogenetic and genetic pathways in therapy-related acute myeloid leukemia.
Therapy-related myelodysplastic syndrome and acute myeloid leukemia (t-MDS/t-AML) are late complications of cytotoxic therapy used in the treatment of malignant diseases. The most common subtype of t-AML ( approximately 75% of cases) develops after exposure to alkylating agents, and is characterized by loss or deletion of chromosome 5 and/or 7 [-5/del(5q), -7/del(7q)], and a poor outcome (media...
متن کاملCytogenetic abnormalities in a plasmacytoma.
By SEnclo MANCINELLI, JOHN R. DURANT, AND WILLIAM J. HAMMACK T SOMEWHAT CONSISTENT cytogenic changes in patients with multiple myeloma have recently been reported. Houston et al.,’ using phytohemagglutinin (PHA) stimulated peripheral blood cells, observed abnormal chromosomes in fifteen of twenty-four patients. The abnormal chromosomes were as large or larger than normal A group members with ce...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2013
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.102.1661